肝窦内皮细胞与肝再生。
Liver sinusoidal endothelial cells and liver regeneration.
机构信息
Division of Gastrointestinal and Liver Diseases and USC Research Center for Liver Disease, Keck School of the University of Southern California, Los Angeles, California 90033, USA.
出版信息
J Clin Invest. 2013 May;123(5):1861-6. doi: 10.1172/JCI66025. Epub 2013 May 1.
Abstract
Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase greatly. In contrast, bone marrow progenitor cells of LSECs (BM SPCs), which are rich in HGF, are recruited to the liver after injury. This Review examines liver regeneration from the perspective that BM SPCs that have been recruited to the liver, rather than mature LSECs, drive liver regeneration.
摘要
肝窦内皮细胞（LSECs）长期以来一直被认为有助于肝损伤后的肝脏再生。在正常肝脏中，HGF 的主要细胞来源是肝星状细胞，但在肝损伤后，HGF 的表达被认为在增殖的 LSECs 中显著增加。然而，新出现的数据表明，即使在损伤后，LSEC 的 HGF 表达也不会大大增加。相反，富含 HGF 的 LSEC 的骨髓祖细胞（BM SPCs）在损伤后被招募到肝脏。这篇综述从肝损伤后被招募到肝脏的 BM SPCs 而不是成熟的 LSECs 推动肝脏再生的角度来探讨肝脏再生。
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