Reviron D, Auquier P, Giusiano B, Maurin N, Sambuc R, Giraud F
Laboratoire de santé publique, Faculté de Médecine, Marseille.
Arch Fr Pediatr. 1990 Apr;47(4):255-6.
Screening for phenylketonuria and hypothyroidism in neonates is currently performed on blood samples collected on the 5th day of life. The efficacy of blood-sampling is evaluated subsequently. Double-sampled and non-sampled children are not always identified. We present a system which provides complete control of child, and was tested experimentally over one year on the 4,260 births in a maternity hospital. The sampling done by the maternity hospital as very thorough: only 0.47% of the children were not sampled spontaneously (ET = 1.07 10(-3)). The sampling of children transferred to pediatric units before the 5th day was a little less rigorous: 6.06% were not sampled before the telephone reminder (ET = 1.86 10(-2)). After a year our system ensured a 100% sampling after identification and telephone reminder for non sampled children, and allowed us to spot and count cases of double-sampling.
目前，新生儿苯丙酮尿症和甲状腺功能减退症的筛查是在出生后第5天采集的血样上进行的。随后对采血效果进行评估。双采样和未采样的儿童并不总是能被识别出来。我们提出了一个能对儿童进行全面管控的系统，该系统在一家妇产医院对4260例分娩进行了为期一年的实验测试。妇产医院的采血工作非常彻底：只有0.47%的儿童未被自动采样（估计误差=1.07×10⁻³）。在第5天之前转至儿科病房的儿童的采血工作稍欠严格：在电话提醒之前，6.06%的儿童未被采样（估计误差=1.86×10⁻²）。一年后，我们的系统在识别并电话提醒未采样儿童后确保了100%的采样率，还让我们能够发现并统计双采样病例。
