Department of Neurosurgery, Ministry of Health, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Acta Neurochir (Wien). 2013 Aug;155(8):1531-7. doi: 10.1007/s00701-013-1726-9. Epub 2013 May 1.
In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model.
Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, and SAH + drug treatment group that received ZNS. In the treatment group, the subjects were given ZNS for 3 days after the SAH. Hippocampal sections were evaluated for neural tissue degeneration. Basilar artery lumen areas and arterial wall thickness were also measured in all groups.
The mean luminal area of the SAH + ZNS was significantly greater than the SAH + saline group. In addition, the arterial wall thickness of SAH + ZNS group was significantly thinner than the SAH + saline group. The neuronal degeneration scores of the hippocampal CA1 regions in the SAH + ZNS group were significantly lower than the SAH + saline treatment animals.
These results indicate that ZNS has a vasodilatatory effect on the basilar artery and a neuronal protective effect in the CA1 region of the hippocampus in a rabbit SAH model.
在这项研究中，我们研究了一种新型抗癫痫药物佐米曲普坦（ZNS）对兔蛛网膜下腔出血（SAH）模型基底动脉和海马的影响。
使用三组新西兰白兔：假手术（非 SAH）组、SAH+盐水组和 SAH+药物治疗组，后者在 SAH 后接受 ZNS 治疗 3 天。评估海马切片的神经组织退变。测量所有组的基底动脉管腔面积和动脉壁厚度。
SAH+ZNS 的平均管腔面积明显大于 SAH+盐水组。此外，SAH+ZNS 组的动脉壁厚度明显小于 SAH+盐水组。SAH+ZNS 组海马 CA1 区的神经元退变评分明显低于 SAH+盐水处理的动物。
这些结果表明，ZNS 对兔蛛网膜下腔出血模型的基底动脉具有血管扩张作用，并对海马 CA1 区具有神经元保护作用。
