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边缘型人格障碍患者的联合危机计划:一项随机对照试验中的可行性和结果。

Joint crisis plans for people with borderline personality disorder: feasibility and outcomes in a randomised controlled trial.

机构信息

Health Services & Population Research Department, Institute of Psychiatry, King's College London, UK.

出版信息

Br J Psychiatry. 2013 May;202(5):357-64. doi: 10.1192/bjp.bp.112.117762. Epub 2013 Apr 11.

Abstract

BACKGROUND

People with borderline personality disorder frequently experience crises. To date, no randomised controlled trials (RCTs) of crisis interventions for this population have been published.

AIMS

To examine the feasibility of recruiting and retaining adults with borderline personality disorder to a pilot RCT investigating the potential efficacy and cost-effectiveness of using a joint crisis plan.

METHOD

An RCT of joint crisis plans for community-dwelling adults with borderline personality disorder (trial registration: ISRCTN12440268). The primary outcome measure was the occurrence of self-harming behaviour over the 6-month period following randomisation. Secondary outcomes included depression, anxiety, engagement and satisfaction with services, quality of life, well-being and cost-effectiveness.

RESULTS

In total, 88 adults out of the 133 referred were eligible and were randomised to receive a joint crisis plan in addition to treatment as usual (TAU; n = 46) or TAU alone (n = 42). This represented approximately 75% of our target sample size and follow-up data were collected on 73 (83.0%) participants. Intention-to-treat analysis revealed no significant differences in the proportion of participants who reported self-harming (odds ratio (OR) = 1.9, 95% CI 0.53-6.5, P = 0.33) or the frequency of self-harming behaviour (rate ratio (RR) = 0.74, 95% CI 0.34-1.63, P = 0.46) between the two groups at follow-up. No significant differences were observed between the two groups on any of the secondary outcome measures or costs.

CONCLUSIONS

It is feasible to recruit and retain people with borderline personality disorder to a trial of joint crisis plans and the intervention appears to have high face validity with this population. However, we found no evidence of clinical efficacy in this feasibility study.

摘要

背景

边缘型人格障碍患者经常会经历危机。迄今为止,尚未发表针对该人群的危机干预的随机对照试验(RCT)。

目的

研究招募和保留边缘型人格障碍成年患者参加一项试点 RCT 的可行性,该 RCT 旨在研究使用联合危机计划的潜在疗效和成本效益。

方法

一项针对社区居住的边缘型人格障碍成年患者的联合危机计划的 RCT(试验注册:ISRCTN61354142)。主要结局测量指标是随机分组后 6 个月内的自伤行为发生情况。次要结局包括抑郁、焦虑、对服务的参与和满意度、生活质量、幸福感和成本效益。

结果

在总共被转介的 133 名患者中,有 88 名符合条件,并被随机分配接受联合危机计划,除了接受常规治疗(TAU;n=46)或仅接受 TAU(n=42)。这大约是我们目标样本量的 75%,并对 73 名(83.0%)参与者进行了随访数据收集。意向治疗分析显示,报告自伤的参与者比例(优势比(OR)=1.9,95%CI 0.53-6.5,P=0.33)或随访时自伤行为的频率(率比(RR)=0.74,95%CI 0.34-1.63,P=0.46)在两组之间没有显著差异。两组在任何次要结局测量或成本方面均无显著差异。

结论

招募和保留边缘型人格障碍患者参加联合危机计划试验是可行的,并且该干预措施似乎在该人群中具有很高的表面有效性。然而,我们在这项可行性研究中没有发现临床疗效的证据。

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