Mohammadi Hadi, Mequanint Kibret, Herzog Walter
School of Engineering, Faculty of Applied Science, The University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada.
Proc Inst Mech Eng H. 2013 Apr;227(4):402-20. doi: 10.1177/0954411912470239. Epub 2013 Jan 23.
This review focuses on the modeling of articular cartilage (at the tissue level), chondrocyte mechanobiology (at the cell level) and a combination of both in a multiscale computation scheme. The primary objective is to evaluate the advantages and disadvantages of conventional models implemented to study the mechanics of the articular cartilage tissue and chondrocytes. From monophasic material models as the simplest form to more complicated multiscale theories, these approaches have been frequently used to model articular cartilage and have contributed significantly to modeling joint mechanics, addressing and resolving numerous issues regarding cartilage mechanics and function. It should be noted that attentiveness is important when using different modeling approaches, as the choice of the model limits the applications available. In this review, we discuss the conventional models applicable to some of the mechanical aspects of articular cartilage such as lubrication, swelling pressure and chondrocyte mechanics and address some of the issues associated with the current modeling approaches. We then suggest future pathways for a more realistic modeling strategy as applied for the simulation of the mechanics of the cartilage tissue using multiscale and parallelized finite element method.
本综述聚焦于关节软骨建模（组织层面）、软骨细胞力学生物学（细胞层面）以及在多尺度计算方案中将二者结合。主要目的是评估用于研究关节软骨组织和软骨细胞力学的传统模型的优缺点。从最简单形式的单相材料模型到更复杂的多尺度理论，这些方法经常被用于对关节软骨进行建模，并在模拟关节力学、解决众多有关软骨力学和功能的问题方面做出了重大贡献。应当注意的是，使用不同建模方法时需谨慎，因为模型的选择会限制可用的应用。在本综述中，我们讨论适用于关节软骨某些力学方面（如润滑、肿胀压力和软骨细胞力学）的传统模型，并阐述当前建模方法相关的一些问题。然后，我们提出未来的途径，以采用多尺度和并行有限元方法，实现更逼真的建模策略来模拟软骨组织力学。
