降钙素基因相关肽对雏鸡血浆钙水平的双重作用。

A dual effect of calcitonin gene-related peptide on plasma calcium levels in the chick.

作者信息

Bevis P J, Zaidi M, MacIntyre I

机构信息

Department of Cellular and Molecular Sciences, St. George's Hospital Medical School, London, UK.

出版信息

Biochem Biophys Res Commun. 1990 Jun 29;169(3):846-50. doi: 10.1016/0006-291x(90)91970-4.

DOI:10.1016/0006-291x(90)91970-4

PMID:2363727

Abstract

Calcitonin gene-related peptide (CGRP) lowers plasma calcium in the rat and inhibits bone resorption by isolated rat osteoclasts. In our preliminary studies we found that rat CGRP elevates plasma calcium levels in the chick, a response that was somewhat similar to that of parathyroid hormone. Here, we report that human CGRP (alpha) produces a concentration-dependent elevation of plasma calcium levels. The two peptides did not follow precisely the same time course. Whereas at 15 minutes CGRP produced hypocalcaemia relative to the control plasma calcium levels, at 30 minutes both CGRP and PTH were found to be hypercalcaemic. These studies suggest that CGRP initially interacts with the calcitonin receptor to produce a calcitonin-like effect, which is followed by hypercalcaemia presumably by antagonising the action of endogenous circulating calcitonin.

摘要

降钙素基因相关肽（CGRP）可降低大鼠的血钙水平，并抑制离体大鼠破骨细胞的骨吸收。在我们的初步研究中，我们发现大鼠CGRP可提高雏鸡的血钙水平，这一反应与甲状旁腺激素的反应有些相似。在此，我们报告人CGRP（α）可使血钙水平呈浓度依赖性升高。这两种肽的时间进程并不完全相同。在15分钟时，相对于对照血浆钙水平，CGRP导致血钙过少，而在30分钟时，发现CGRP和甲状旁腺激素均导致血钙过多。这些研究表明，CGRP最初与降钙素受体相互作用产生降钙素样效应，随后可能通过拮抗内源性循环降钙素的作用而导致血钙过多。