肿瘤细胞死亡受体-配体系统与细胞死亡和炎症
Death receptor-ligand systems in cancer, cell death, and inflammation.
机构信息
Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, London WC1E 6BT, United Kingdom.
出版信息
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a008698. doi: 10.1101/cshperspect.a008698.
Abstract
The discovery of tumor necrosis factor (TNF) marked the beginning of one of the most fascinating journeys in modern biomedical research. For the moment, this journey has culminated in the development of drugs that inhibit TNF. TNF blockers have revolutionized the treatment of many chronic inflammatory diseases. Yet, the journey seems far from over. TNF is the founding member of a family of cytokines with crucial functions in cell death, inflammation, and cancer. Some of these factors, most prominently TNF, CD95L, and TRAIL, can induce cell death. The receptors that mediate this signal are therefore referred to as death receptors, even though they also activate other signals. Here I will take you on a journey into the discovery and study of death receptor-ligand systems and how this inspired new concepts in cancer therapy and our current understanding of the interplay between cell death and inflammation.
摘要
肿瘤坏死因子（TNF）的发现标志着现代生物医学研究中最引人入胜的旅程之一的开始。到目前为止，这一旅程已经达到了开发抑制 TNF 的药物的高潮。TNF 阻滞剂彻底改变了许多慢性炎症性疾病的治疗方法。然而，这个旅程似乎还远未结束。TNF 是细胞因子家族的创始成员，在细胞死亡、炎症和癌症中具有至关重要的功能。其中一些因子，最突出的是 TNF、CD95L 和 TRAIL，能够诱导细胞死亡。介导这种信号的受体因此被称为死亡受体，尽管它们也激活其他信号。在这里，我将带您踏上发现和研究死亡受体配体系统的旅程，以及这如何激发了癌症治疗的新概念，以及我们目前对细胞死亡和炎症之间相互作用的理解。
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