Department of Neurology, Mitate Hospital, Tagawa, Japan.
Ther Clin Risk Manag. 2013;9:171-6. doi: 10.2147/TCRM.S43811. Epub 2013 Apr 22.
Vitamin D supplementation is suggested to reduce the risk of falls in older institutionalized or ambulatory individuals by 20%. The present study was undertaken to address the reduced risk, by vitamin D supplementation, of falls and hip fractures in patients with vascular Parkinsonism (VP) and Parkinson's disease (PD).
In the open-label-study, 94 elderly patients with VP and 92 age-matched patients with PD were followed for 2 years. All patients received 1200 IU ergocalciferol daily. The number of falls per person and incidence of hip fractures were compared between the two groups.
At baseline, serum 25-hydroxyvitamin D (25-OHD) levels were in the deficient range (<25 nmol/L) in all patients, and vitamin D treatment enhanced serum 25-OHD and 1,25-dihydroxyvitamin D levels in both groups. Improved muscle strength of lower extremities was observed in both groups. There was significant difference between the two groups in the number of falls per subject during the 2 years (1.9 ± 0.5 in the PD group and 0.8 ± 0.4 in the VP group, P < 0.001). Hip fractures occurred in seven of 88 in the PD group and one in 90 of the VP group during the 2-year study period (P = 0.035).
It is suggested that vitamin D decreases falls and hip fractures in VP by increasing muscle strength but not in PD.
维生素 D 补充被认为可以降低 20%的老年人在机构或行动不便人群中跌倒的风险。本研究旨在探讨维生素 D 补充对血管性帕金森病（VP）和帕金森病（PD）患者跌倒和髋部骨折风险降低的作用。
在开放性研究中，94 名老年 VP 患者和 92 名年龄匹配的 PD 患者接受了 2 年的随访。所有患者每天接受 1200IU 骨化醇治疗。比较两组患者的跌倒人数和髋部骨折发生率。
在基线时，所有患者的血清 25-羟维生素 D（25-OHD）水平均处于不足范围（<25nmol/L），维生素 D 治疗可提高两组患者的血清 25-OHD 和 1,25-二羟维生素 D 水平。两组患者的下肢肌肉力量均有改善。在 2 年期间，两组患者的跌倒人数存在显著差异（PD 组为 1.9±0.5，VP 组为 0.8±0.4，P<0.001）。在 2 年研究期间，PD 组有 88 例中的 7 例和 VP 组 90 例中的 1 例发生髋部骨折（P=0.035）。
维生素 D 通过增加肌肉力量降低 VP 患者的跌倒和髋部骨折风险，但对 PD 患者无此作用。
