亚硒酸钠对秀丽隐杆线虫铅诱导神经毒性的保护作用。

Protective efficacy of selenite against lead-induced neurotoxicity in Caenorhabditis elegans.

机构信息

Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan.

出版信息

PLoS One. 2013 Apr 26;8(4):e62387. doi: 10.1371/journal.pone.0062387. Print 2013.

BACKGROUND

Selenium is an essential micronutrient that has a narrow exposure window between its beneficial and toxic effects. This study investigated the protective potential of selenite (IV) against lead (Pb(II))-induced neurotoxicity in Caenorhabditis elegans.

PRINCIPAL FINDINGS

The results showed that Se(IV) (0.01 µM) pretreatment ameliorated the decline of locomotion behaviors (frequencies of body bends, head thrashes, and reversal ) of C. elegans that are damaged by Pb(II) (100 µM) exposure. The intracellular ROS level of C. elegans induced by Pb(II) exposure was significantly lowered by Se(IV) supplementation prior to Pb(II) exposure. Finally, Se(IV) protects AFD sensory neurons from Pb(II)-induced toxicity.

CONCLUSIONS

Our study suggests that Se(IV) has protective activities against Pb(II)-induced neurotoxicity through its antioxidant property.

背景

硒是一种必需的微量元素，其有益和有毒作用之间的暴露窗口很窄。本研究调查了亚硒酸盐（IV）对秀丽隐杆线虫中铅（Pb（II））诱导的神经毒性的保护潜力。

主要发现

结果表明，硒（IV）（0.01 µM）预处理可改善因 Pb（II）（100 µM）暴露而受损的秀丽隐杆线虫的运动行为（体弯曲频率、头部猛击和反转）下降。Pb（II）暴露前补充硒（IV）可显著降低 Pb（II）诱导的秀丽隐杆线虫的细胞内 ROS 水平。最后，硒（IV）可保护 AFD 感觉神经元免受 Pb（II）诱导的毒性。