Department of Dermatology, Elazig Education and Research Hospital , Elazig , Turkey.
J Dermatolog Treat. 2013 Dec;24(6):454-7. doi: 10.3109/09546634.2013.800181. Epub 2013 May 31.
Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin.
We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA.
The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period.
In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05).
Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.
肛门瘙痒症（PA）定义为影响肛周皮肤的强烈慢性瘙痒。
我们旨在确定外用他克莫司治疗患有 PA 的特应性皮炎（AD）患者的疗效。
本研究纳入 32 名患有 AD 且伴有 PA 的患者。患者被随机分为两组。共有 16 名患者使用 0.03%他克莫司软膏，16 名患者使用凡士林作为安慰剂。所有组均在肛周区域每天两次应用局部治疗，持续 4 周。在 2 周洗脱期后，治疗再持续 4 周。
本研究共纳入 32 名患有 AD 且肛门瘙痒难治的患者。既往治疗均未取得成功。与安慰剂组相比，治疗第 4 周和第 6 周时，他克莫司组的 EASI、DLQI 和瘙痒评分均有显著下降（p<0.05）。
外用他克莫司治疗对控制 AD 患者的持续性 PA 耐受良好且有效。
