Clinical and Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy.
Int J Cardiol. 2013 Sep 30;168(2):680-7. doi: 10.1016/j.ijcard.2013.03.133. Epub 2013 Apr 30.
Cardiotoxicity caused by chemotherapy is a concerning reality plaguing oncologists and cardiologists. The coexistence of cancer and cardiovascular diseases in the same patient is more common due to the aging population and improvement of chemotherapeutic drug effectiveness. We review the incidence and clinical features of cardiotoxicity caused by some of the most common chemotherapeutic drugs to provide the cardiologist with information regarding general cardiovascular toxicity, early left ventricular dysfunction detection, cardiac damage prevention and follow-up. In conclusion, awareness of this emerging problem has important clinical implications as only highly specialized care will prevent patients who successfully overcome cancer from being defeated by the side effects of anticancer therapy.
化疗引起的心脏毒性是困扰肿瘤学家和心脏病学家的一个现实问题。由于人口老龄化和化疗药物效果的提高,患有癌症和心血管疾病的患者同时存在的情况更为常见。我们回顾了一些最常见的化疗药物引起的心脏毒性的发生率和临床特征,为心脏病专家提供了有关一般心血管毒性、早期左心室功能障碍检测、心脏损伤预防和随访的信息。总之,对这一新兴问题的认识具有重要的临床意义,只有高度专业化的护理才能防止那些成功战胜癌症的患者因抗癌治疗的副作用而败下阵来。