Kale Yusuf, Aydemir Ozge, Ceylan Ozben, Bas Ahmet Yagmur, Demirel Nihal
Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Department of Neonatology, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Pediatr Neonatol. 2015 Aug;56(4):268-70. doi: 10.1016/j.pedneo.2013.03.015. Epub 2013 Apr 30.
Dexamethasone is widely used in preterm infants with severe pulmonary disease. Hypertrophic cardiomyopathy (HCM) is a transient side effect observed after multiple doses of dexamethasone. We report a preterm infant with myocardial hypertrophy after a single dose of dexamethasone (0.5 mg/kg) used to treat laryngeal edema secondary to prolonged intubation. A benign course was observed without left ventricular outflow tract obstruction and with recovery within 4 weeks. Myocardial effects of dexamethasone may be independent of dose and duration of treatment. The risk/benefit ratio must be carefully considered before using even a single dose of dexamethasone in preterm infants.
地塞米松广泛应用于患有严重肺部疾病的早产儿。肥厚型心肌病（HCM）是多次使用地塞米松后观察到的一种短暂副作用。我们报告一例早产儿，在单次使用地塞米松（0.5mg/kg）治疗因长时间插管继发的喉水肿后出现心肌肥厚。观察到病程良性，无左心室流出道梗阻，且在4周内恢复。地塞米松对心肌的影响可能与治疗剂量和疗程无关。在早产儿中即使使用单剂量地塞米松之前，也必须仔细考虑风险/获益比。
