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[豚鼠的模拟潜水测试]

[Simulated diving tests in guinea pigs].

作者信息

Wang L

机构信息

Navy General Hospital, Beijing.

出版信息

Zhonghua Er Bi Yan Hou Ke Za Zhi. 1990;25(2):66-8, 125.

PMID:2363980
Abstract

Simulated diving tests with helium oxygen mixture were carried out in guinea pigs. The water depth was 100M (1.1Mpa). Hearing ability of guinea pigs changes and inner ear lesions occurred after decompression. The tests proved that hearing changes were especially evident in 0.5-1.0 kHz in slow decompression group and were induced by barotrauma. In the fast decompression group, the hearing impairment in 0.5-1.0 kHz range was more prominent than that in the 2-8kHz. The hearing thresholds of the 3 guinea pigs having vestibular symptoms (nystagmus, rotatory movement of the body) were elevated in the 0.5-8.0 kHz range. The vestibular symptoms and the elevation of hearing threshold of these 3 guinea pigs were induced by inner ear decompression sickness. The middle ears showed bleeding, effusion and cell infiltration. Ultrastructural changes were derangement and lodging of stereocilia of hair cells and changes of organelle.

摘要

用氦氧混合气对豚鼠进行模拟潜水试验。水深为100米(1.1兆帕)。减压后豚鼠听力发生变化并出现内耳损伤。试验证明,缓慢减压组在0.5 - 1.0千赫听力变化尤为明显,是由气压伤引起的。快速减压组中,0.5 - 1.0千赫范围内的听力损伤比2 - 8千赫范围内更突出。3只出现前庭症状(眼球震颤、身体旋转运动)的豚鼠在0.5 - 8.0千赫范围内听力阈值升高。这3只豚鼠的前庭症状和听力阈值升高是由内耳减压病引起的。中耳出现出血、积液和细胞浸润。超微结构变化为毛细胞静纤毛排列紊乱和倒伏以及细胞器改变。

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