慢性乙型肝炎病毒感染者中隐匿性丙型肝炎病毒感染的高发生率。

High prevalence of occult hepatitis C virus infection in patients with chronic hepatitis B virus infection.

机构信息

Fundación para el Estudio de las Hepatitis Virales, Madrid, Spain.

出版信息

J Med Microbiol. 2013 Aug;62(Pt 8):1235-1238. doi: 10.1099/jmm.0.058297-0. Epub 2013 May 2.

DOI:10.1099/jmm.0.058297-0

Abstract

Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on the clinical course of HBV infection.

摘要

在血清中检测不到针对丙型肝炎病毒（HCV）的抗体和病毒 RNA 的情况下发生的 HCV 感染称为隐匿性 HCV 感染。其在慢性乙型肝炎病毒（HBV）感染中的流行率和临床意义尚不清楚。对 52 例慢性 HBV 感染患者和 21 例（40%）患者的肝组织样本进行了 HCV RNA 检测，这些患者的病毒 RNA 检测均为阳性（隐匿性 HCV 感染）。结果发现，隐匿性 HCV 感染患者的肝纤维化更为常见，纤维化评分显著高于阴性患者，这表明隐匿性 HCV 感染可能对 HBV 感染的临床病程产生影响。