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Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo.

作者信息

Soderquist R, Bates D J P, Danilov A V, Eastman A

机构信息

1] Department of Pharmacology and Toxicology, Giesel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH, USA [2] Norris Cotton Cancer Center, Giesel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH, USA.

出版信息

Leukemia. 2013 Nov;27(11):2262-4. doi: 10.1038/leu.2013.138. Epub 2013 May 3.

Abstract
摘要

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本文引用的文献

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
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Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood. 2012 Jun 14;119(24):5807-16. doi: 10.1182/blood-2011-12-400929. Epub 2012 Apr 26.
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Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.
Clin Cancer Res. 2012 Jan 15;18(2):487-98. doi: 10.1158/1078-0432.CCR-11-1440. Epub 2011 Nov 29.
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Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
Cell Death Differ. 2011 May;18(5):864-73. doi: 10.1038/cdd.2010.152. Epub 2010 Nov 26.
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Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.
Blood. 2011 Jan 6;117(1):156-64. doi: 10.1182/blood-2010-01-262808. Epub 2010 Oct 22.
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An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer.
Clin Cancer Res. 2009 May 1;15(9):3172-6. doi: 10.1158/1078-0432.CCR-08-2985. Epub 2009 Apr 14.
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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood. 2009 Apr 30;113(18):4403-13. doi: 10.1182/blood-2008-08-173310. Epub 2008 Nov 13.

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