2-咪唑硫酮可保护抗坏血酸免受铜诱导的氧化作用。

2-Imidazolethiones protect ascorbic acid from oxidation induced by copper.

作者信息

Smith R C, Gore J Z

机构信息

Department of Animal and Dairy Sciences, Auburn University 36849-5415.

出版信息

Biochim Biophys Acta. 1990 Jun 20;1034(3):263-7. doi: 10.1016/0304-4165(90)90048-2.

DOI:10.1016/0304-4165(90)90048-2

PMID:2364083

Abstract

The oxidation of ascorbic acid to dehydroascorbic acid was accelerated by metal ions such as copper. This stimulation of ascorbate oxidation was inhibited by the addition of 2-imidazolethiones and other sulfhydryl-containing compounds, but not by 2-imidazolones or phenytoin. Although the 2-imidazolethiones interacted with copper, as shown by a decrease in the ultraviolet absorbance of the compounds, the product formed still protected ascorbate from oxidation. The 2-imidazolethiones are proposed to complex copper through their free -SH groups.

摘要

抗坏血酸氧化为脱氢抗坏血酸的过程会被诸如铜等金属离子加速。抗坏血酸氧化的这种促进作用会被添加2-咪唑硫酮及其他含巯基的化合物所抑制，但不会被2-咪唑酮或苯妥英抑制。尽管2-咪唑硫酮与铜发生了相互作用，这可通过化合物紫外吸光度的降低表现出来，但形成的产物仍能保护抗坏血酸不被氧化。有人提出2-咪唑硫酮通过其游离的巯基与铜形成络合物。