Section on Endocrinology Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
J Clin Endocrinol Metab. 2013 Jul;98(7):2667-78. doi: 10.1210/jc.2013-1123. Epub 2013 May 2.
Cushing syndrome (CS) in children is associated with residual impairment in measures of health-related quality of life, even after successful resolution of hypercortisolemia, highlighting the need for early identification of morbidities and improvements in long-term management of these patients.
A PubMed, Scopus, and Web of Science search of articles from 1900 onward identified available studies related to quality of life and complications of pediatric CS as well as important historical articles. This review summarizes studies through November 2012 and highlights recent developments.
A review of the literature identifies significant morbidities associated with CS of pediatric onset, which must not be treated in isolation. CS affects children and adolescents in many ways that are different than adults. Post-treatment challenges for the child or adolescent treated for CS include: optimize growth and pubertal development, normalize body composition, and promote psychological health and cognitive maturation. All these factors impact health-related quality of life, which is an important outcome measure to assess the burden of disease as well as the effect of treatment. Future research efforts are needed to improve management of the physical, psychological, and emotional aspects of this disease in order to diminish the residual impairments experienced by the pediatric CS patient population.
儿童库欣综合征（CS）与健康相关生活质量的衡量标准存在残余损害相关，即使在皮质醇过多症成功解决后也是如此，这突出表明需要早期识别病态，并改善这些患者的长期管理。
对 1900 年以来 PubMed、Scopus 和 Web of Science 中与儿童 CS 的生活质量和并发症相关的现有研究以及重要的历史文献进行了搜索。本综述总结了截至 2012 年 11 月的研究，并强调了最近的发展。
对文献的回顾确定了与儿科 CS 相关的重大病态，这些病态绝不能孤立地对待。CS 以不同于成年人的方式影响儿童和青少年。接受 CS 治疗的儿童或青少年的治疗后挑战包括：优化生长和青春期发育、使身体成分正常化、促进心理健康和认知成熟。所有这些因素都影响健康相关的生活质量，这是评估疾病负担以及治疗效果的重要结果衡量标准。需要开展未来的研究工作，以改善这种疾病的身体、心理和情感方面的管理，从而减少儿科 CS 患者群体所经历的残余损害。
