[氟哌啶醇对白血病P-388细胞中阿霉素蓄积的影响以及对氟哌啶醇与阿霉素联合用药的诱导抗性]
[The effect of finoptin on doxorubicin accumulation in leukemia P-388 cells with induced resistance to the combination of finoptin and doxorubicin].
作者信息
Moroz L V, Donenko F V, Borovkova N B, Sitdikova S M, Kabieva A O
出版信息
Biull Eksp Biol Med. 1990 Mar;109(3):290-2.
Using hybrid mice BDF1 doxorubicin (Dx) accumulation has been determined in leukemia P388 cells (P388/0), P388 cells with induced resistance to Dx (P388/Dx) and P388 cells with induced resistance to the finoptin (Fp) + Dx combination (P388/Fp + Dx). It has been shown that Fp doesn't affect Dx accumulation in or elimination from leukemia cells P388/0 or P388/Fp + Dx. The resistance of P388/Fp + Dx cells to the Fp + Dx combination develops during 6 passages. It can be concluded that Fp application doesn't abolish the problem of tumor cells' resistance to cytostatics.
利用杂交小鼠，已测定白血病P388细胞（P388/0）、对阿霉素（Dx）诱导耐药的P388细胞（P388/Dx）以及对芬普替丁（Fp）+Dx联合用药诱导耐药的P388细胞（P388/Fp + Dx）中BDF1阿霉素（Dx）的蓄积情况。结果表明，Fp不影响白血病细胞P388/0或P388/Fp + Dx对Dx的摄取或清除。P388/Fp + Dx细胞对Fp + Dx联合用药的耐药性在6次传代过程中形成。可以得出结论，应用Fp并不能消除肿瘤细胞对细胞抑制剂耐药的问题。
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