Tactus Addiction Treatment, 7400 AD Deventer, the Netherlands; Nijmegen Institute for Scientist-Practitioners in Addiction, 6500 HE Nijmegen, the Netherlands.
Compr Psychiatry. 2013 Oct;54(7):911-7. doi: 10.1016/j.comppsych.2013.03.021. Epub 2013 May 2.
Previous research identified alexithymia as a potential risk factor for substance use disorders (SUD). More insight into the relation between alexithymia and SUD is needed in order to treat SUD effectively. Therefore, we investigated whether a familial vulnerability to alcoholism relates to the presence and severity of alexithymia in SUD patients.
Hospitalized, abstinent SUD-patients (n=187), were assessed with the Toronto Alexithymia Scale (TAS-20) and Addiction Severity Index (EuropASI). A maternal, paternal, and total continuous measure of the Family History of Alcohol (FHA) was developed. Kruskal-Wallis tests and Spearman correlations were used to relate the composite scores of FHA to alexithymia as a categorical and continuous measure. Multivariate regression models were performed to control for the effects of confounders on the relation between FHA and alexithymia.
Compared to moderate (33%) and low (17%) alexithymic SUD-patients, high alexithymic (50%) patients were more likely to have fathers with alcohol problems (P=0.004). Such a difference was not found for mothers with alcohol problems. The composite FHA-score was significantly associated with alexithymia (Rs=.19, P=0.01). However, only a paternal FHA, independent from disturbed family functioning, related to the degree of alexithymia (β=.13, P=0.06), especially to the Difficulty Identifying Feelings as measured by the TAS-20 (β=.16, P=0.02).
The relation between a paternal FHA and a higher degree of alexithymia in SUD-patients suggests that alexithymia could mediate the familiality of alcoholism or SUD in the paternal line.
先前的研究将述情障碍确定为物质使用障碍(SUD)的潜在风险因素。为了有效地治疗 SUD,需要更深入地了解述情障碍与 SUD 之间的关系。因此,我们调查了酒精中毒的家族易感性是否与 SUD 患者述情障碍的存在和严重程度有关。
对住院的、戒酒的 SUD 患者(n=187)进行多伦多述情障碍量表(TAS-20)和成瘾严重程度指数(EuropASI)评估。开发了一种用于评估家族酒精史(FHA)的连续母体、父体和总测量方法。使用 Kruskal-Wallis 检验和 Spearman 相关系数来将 FHA 的综合评分与作为分类和连续测量的述情障碍相关联。进行多元回归模型来控制混杂因素对 FHA 与述情障碍之间关系的影响。
与中度(33%)和低度(17%)述情障碍的 SUD 患者相比,高度述情障碍(50%)的患者更有可能有酗酒的父亲(P=0.004)。对于有酗酒问题的母亲,没有发现这种差异。FHA 综合评分与述情障碍显著相关(Rs=.19,P=0.01)。然而,只有独立于家庭功能障碍的父体 FHA 与述情障碍的程度相关(β=.13,P=0.06),特别是与 TAS-20 测量的“难以识别感受”(β=.16,P=0.02)相关。
SUD 患者的父体 FHA 与更高程度的述情障碍之间的关系表明,述情障碍可能在父系中介导酒精中毒或 SUD 的家族性。