Hematology Department, General Hospital, Tianjin Medical University, Tianjin, China.
Leuk Res. 2013 Aug;37(8):907-10. doi: 10.1016/j.leukres.2013.04.008. Epub 2013 May 2.
The increased LSC in MDS has correlation with the progression to AML, which the mechanism of immune evasion is unclear. Our study showed the expression of CD47 on LSC of the patients in high-risk MDS based on IPSS/WPSS score was higher than that of in low-risk MDS and controls. The level of CD47 on erythroblast of MDS patients had a significant positive correlation with their peripheral RBC count. It suggested that the proportion of CD34(+)CD38(-)CD47(+) cells increased in high-risk MDS which might protect LSC from avoiding phagocytosis, and low-expression of CD47 on erythroblast in MDS might be correlated to anemia.
骨髓增生异常综合征（MDS）中 LSC 的增加与向 AML 的进展相关，其免疫逃逸机制尚不清楚。我们的研究表明，基于 IPSS/WPSS 评分，高危 MDS 患者 LSC 上 CD47 的表达高于低危 MDS 和对照组。MDS 患者红细胞上 CD47 的水平与外周 RBC 计数呈显著正相关。这表明高危 MDS 中 CD34(+)CD38(-)CD47(+)细胞的比例增加，可能保护 LSC 免受吞噬作用，而 MDS 中红细胞上 CD47 的低表达可能与贫血相关。
