Yan Hui-tong, Luo Yu-kun, Tang Wen-bo, Jiao Zi-yu, Yao Chun-xiao, Lv Fa-qin, Tang Jie
Department of Ultrasound, General Hospital of the People's Liberation Army, Beijing, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Apr;35(2):217-20. doi: 10.3881/j.issn.1000-503X.2013.02.016.
To investigate the value of liver stiffness measured by acoustic radiation force impulse imaging(ARFI) in assessing hepatic functional reserve in patients with space-occupying lesions in the liver.
Sixty-three patients with space-occupying lesions in the liver were enrolled. Liver stiffness (LS) measurements with ARFI and indocyanine green(ICG) retention test were performed in the same day, and plasma clearance rate of indocyanine green(ICG-K), ICG retention at 15 minutes(ICGR15) as well as 10 effective values of LS were recorded. The correlation between Child-Pugh score, ICGR15, ICG-K, and LS were evaluated.
The LS measurements with ARFI failed in one patient. A strong correlation between LS and ICGR15(r=0.789, P<0.01) and an inverse correlation between LS and ICG-K(r=-0.738, P<0.01) were observed. Besides, there was a significant correlation between LS measurements and Child-Pugh score(r=0.929, P<0.01) . The LS significantly differed among patients with Child-Pugh class A, B, and C(P<0.01) .
ARFI is a simple, feasible and non-invasive method for assessing hepatic functional reserve in patients with space-occupying lesions in the liver.
探讨应用声学辐射力脉冲成像（ARFI）测量肝脏硬度值在评估肝脏占位性病变患者肝功能储备中的价值。
纳入63例肝脏占位性病变患者。于同日进行ARFI测量肝脏硬度值（LS）及吲哚菁绿（ICG）滞留试验，记录吲哚菁绿血浆清除率（ICG-K）、15分钟吲哚菁绿滞留率（ICGR15）以及10个有效的LS值。评估Child-Pugh评分、ICGR15、ICG-K与LS之间的相关性。
1例患者ARFI测量LS失败。观察到LS与ICGR15呈强相关（r=0.789，P<0.01），LS与ICG-K呈负相关（r=-0.738，P<0.01）。此外，LS测量值与Child-Pugh评分之间存在显著相关性（r=0.929，P<0.01）。Child-Pugh A、B、C级患者的LS有显著差异（P<0.01）。
ARFI是评估肝脏占位性病变患者肝功能储备的一种简单、可行且无创的方法。
