Université de Lyon, CARMEN INSERM U1060, INSA-Lyon, F-69621 Villeurbanne, France.
J Theor Biol. 2013 Sep 7;332:89-95. doi: 10.1016/j.jtbi.2013.04.025. Epub 2013 Apr 30.
Adipocytes are cells whose task is to store excess energy as lipid droplets in their cytoplasm. Adipocytes can adapt their size according to the lipid amount to be stored. Adipocyte size variation can reach one order of magnitude inside the same organism which is unique among cells. A striking feature in adipocytes size distribution is the lack of characteristic size since typical size distributions are bimodal. Since energy can be stored and retrieved and adipocytes are responsible for these lipid fluxes, we propose a simple model of size-dependent lipid fluxes that is able to predict typical adipocytes size distribution.
脂肪细胞是将多余的能量作为细胞质中的脂滴储存的细胞。脂肪细胞可以根据要储存的脂质量来调节其大小。在同一个生物体中，脂肪细胞的大小变化可以达到一个数量级，这在细胞中是独一无二的。脂肪细胞大小分布的一个显著特征是缺乏特征尺寸，因为典型的尺寸分布是双峰的。由于能量可以储存和回收，而脂肪细胞负责这些脂质通量，我们提出了一个依赖于大小的脂质通量的简单模型，该模型能够预测典型的脂肪细胞大小分布。
