Cotsarelis G, Sun T T, Lavker R M
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Cell. 1990 Jun 29;61(7):1329-37. doi: 10.1016/0092-8674(90)90696-c.
Inconsistent with the view that hair follicle stem cells reside in the matrix area of the hair bulb, we found that label-retaining cells exist exclusively in the bulge area of the mouse hair follicle. The bulge consists of a subpopulation of outer root sheath cells located in the midportion of the follicle at the arrector pili muscle attachment site. Keratinocytes in the bulge area are relatively undifferentiated ultrastructurally. They are normally slow cycling, but can be stimulated to proliferate transiently by TPA. Located in a well-protected and nourished environment, these cells mark the lower end of the "permanent" portion of the follicle. Our findings, plus a reevaluation of the literature, suggest that follicular stem cells reside in the bulge region, instead of the lower bulb. This new view provides insights into hair cycle control and the possible involvement of hair follicle stem cells in skin carcinogenesis.
与毛囊干细胞存在于毛球基质区域的观点不一致的是，我们发现标记保留细胞仅存在于小鼠毛囊的隆突区。隆突由位于毛囊中部立毛肌附着部位的外根鞘细胞亚群组成。隆突区的角质形成细胞在超微结构上相对未分化。它们通常增殖缓慢，但可被佛波酯短暂刺激而增殖。这些细胞位于一个受到良好保护和滋养的环境中，标志着毛囊“永久”部分的下端。我们的发现，加上对文献的重新评估，表明毛囊干细胞存在于隆突区，而非毛球下部。这一新观点为毛发周期调控以及毛囊干细胞可能参与皮肤癌发生提供了见解。
