State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
Nat Prod Rep. 2013 Jun;30(6):869-915. doi: 10.1039/c3np70006b.
Covering: July 2010 to June 2012. Previous review: Nat. Prod. Rep., 2011, 28, 1143-1191. Structurally diverse alkaloids containing five-membered heterocyclic subunits, such as imidazole, oxazole, thiazole, as well as their saturated congeners, are widely distributed in terrestrial and marine organisms and microorganisms. These naturally occurring secondary metabolites often exhibit extensive and pharmacologically important biological activities. The latest progress involving isolation, biological activities, chemical synthetic studies, and biosynthetic pathways of these natural products has been summarized in this review.
2010 年 7 月至 2012 年 6 月。
Nat.Prod. Rep.，2011，28，1143-1191。
含有五元杂环亚基（如咪唑、恶唑、噻唑及其饱和同系物）的结构多样的生物碱广泛分布于陆地和海洋生物及微生物中。这些天然存在的次级代谢产物通常表现出广泛且具有重要药理学意义的生物活性。本综述总结了这些天然产物的最新分离、生物活性、化学合成研究和生物合成途径方面的进展。
