Otorhinolaryngology Unit, IRCCS San Raffaele Vita-Salute University, Via Olgettina 60, 20132 Milan, Italy.
Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2365-9. doi: 10.1007/s00405-013-2520-2. Epub 2013 May 4.
Schwannomas are rare and slow growing tumours, arising from Schwann cells which provide myelin; less than 1% of them degenerate into a malignant state. Although most studies are based on acoustic schwannomas, the majority of these tumours are non-vestibular and extracranial. Up to 45% of them can be localised in head and neck districts, where they represent a diagnostic challenge because they are in differential diagnosis with lipoma, brachial cyst, paraganglioma and adenopathy. Between February 2002 and September 2012 our experience considers 18 patients affected by schwannomas localised in the neck in 14 cases, in the oral cavity in 2 cases, in the upper lip in 1 case and finally in the nose in 1 case. A painless neck mass was the major symptom referred, as well as dysphonia and oral pain. Ultrasound scan with fine needle aspiration biopsy was done in half of the group and was diagnostic in 30%, whereas magnetic resonance imaging was diagnostic in 77%, confirming its primary role in diagnostic work-up. The surgical approach was mainly by cervical incision and the intraneural extracapsular enucleation was the technique used without nerve injury in 89% of cases. Follow-up period was 6-120 months and no evidence of relapse was registered.
神经鞘瘤是一种罕见且生长缓慢的肿瘤,起源于提供髓鞘的施万细胞;其中不到 1%会恶变为恶性状态。尽管大多数研究基于听神经鞘瘤,但这些肿瘤的大多数是非前庭和颅外的。多达 45%的肿瘤可定位于头颈部,在这些部位,它们构成了诊断挑战,因为它们需要与脂肪瘤、臂丛囊肿、副神经节瘤和淋巴结病进行鉴别诊断。在 2002 年 2 月至 2012 年 9 月期间,我们的经验包括 18 例位于颈部的神经鞘瘤患者,其中 14 例位于颈部,2 例位于口腔,1 例位于上唇,1 例位于鼻腔。主要的症状是无痛性颈部肿块,以及声音嘶哑和口腔疼痛。一半的患者接受了超声扫描和细针抽吸活检,其中 30%具有诊断价值,而磁共振成像的诊断率为 77%,证实其在诊断性检查中具有主要作用。手术途径主要是经颈部切口,采用神经内囊外剥除术,在 89%的病例中没有神经损伤。随访时间为 6-120 个月,未发现复发证据。