用于肠胃外递送难溶性药物的纳米晶体。
Nanocrystals for the parenteral delivery of poorly water-soluble drugs.
作者信息
Sun Bo, Yeo Yoon
机构信息
Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
出版信息
Curr Opin Solid State Mater Sci. 2012 Dec 1;16(6):295-301. doi: 10.1016/j.cossms.2012.10.004.
Abstract
Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products.
摘要
由于能够改善难溶性药物的溶出度，纳米晶体在制药行业引起了越来越多的关注。纳米晶体可以通过自上而下和自下而上的技术生产，并已被探索用于各种治疗应用。在此，我们综述了纳米晶体的生产方法及其肠胃外应用。我们还讨论了纳米晶体产品开发中仍然存在的挑战。
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