Arean Patricia A
University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA.
Neuropsychiatry (London). 2012 Apr;2(2):135-145. doi: 10.2217/npy.12.15.
This article reviews the potential utility of behavioral interventions in personalized depression treatment. The paper begins with a definition of personalized treatment, moves to current thinking regarding the various causes of depression, and proposes how those causes can be used to inform the selection of behavioral interventions. Two examples from the late-life depression field will illustrate how a team of researchers at Cornell University (NY, USA) and University of California, San Francisco (CA, USA) created a research partnership to select and study behavioral interventions for older adults with risk factors associated with poor response to selective serotonin reuptake inhibitor medications. The paper ends with a discussion of how the process used by the Cornell University-University of California, San Francisco team can be applied to the selection and development of behavioral interventions for other psychiatric disorders.
本文综述了行为干预在个性化抑郁症治疗中的潜在效用。文章开篇对个性化治疗进行了定义，接着阐述了当前关于抑郁症各种病因的观点，并提出如何依据这些病因来指导行为干预的选择。来自老年抑郁症领域的两个例子将说明美国纽约康奈尔大学和美国加利福尼亚州旧金山大学的一组研究人员如何建立研究合作关系，为患有与选择性5-羟色胺再摄取抑制剂药物反应不佳相关风险因素的老年人选择和研究行为干预措施。文章最后讨论了康奈尔大学-旧金山大学团队所采用的方法如何应用于其他精神疾病行为干预措施的选择和开发。
