Wang Yu, Pan Tao, Zhou Na, Ma Furong
Department of Otolaryngology, Third Hospital of Peking University, Beijing 100191, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jan;27(1):8-12.
To evaluate the electrophysiological characteristics of electrically evoked auditory brainstem responses (EABR) and its application in cochlear implantation, especially in evaluating acoustic nerve survival.
An auditory evoked potential instrument was used to record responses and Cochlear Nucleus 24CA implants were used to generate electrical stimulation. We measured EABR in 23 patients with cochlear implants and compared EABR with behavioral measures and neural response telemetry (NRT).
EABR III-V waveforms were recognized in all of the 23 patients. The characteristics and origins of EABR waveforms were similar to those of ABR. The average EABR threshold was (172.61 +/- 14.61) CL. At 20 CL above threshold, the average latencies of Wave III, V were (2.93 +/- 0.18)ms, (4.80 +/- 0.28)ms which were 1-2 ms shorter than ABR latencies. But III-V intervals remained at (1.86 +/- 0.18)ms. EABR thresholds were strongly correlated with behavioral performance and NRT thresholds, while EABR input-output function is correlated with behavioral dynamic range (DR).
EABR is such an effective method to objectively evaluate the function of auditory pathway which can estimate residual spiral ganglion cell count. This is consistent with the foreign study leading to the conclusion that DR reflects spiral ganglion cell survival.
评估电诱发听性脑干反应（EABR）的电生理特性及其在人工耳蜗植入中的应用，尤其是在评估听神经存活方面的应用。
使用听觉诱发电位仪记录反应，并使用耳蜗核24CA植入物进行电刺激。我们对23例人工耳蜗植入患者测量了EABR，并将EABR与行为测听和神经反应遥测（NRT）进行比较。
23例患者均记录到EABR III-V波。EABR波形的特征和起源与ABR相似。EABR平均阈值为（172.61±14.61）CL。在阈值以上20 CL时，波III、V的平均潜伏期分别为（2.93±0.18）ms、（4.80±0.28）ms，比ABR潜伏期短1-2 ms。但III-V间期保持在（1.86±0.18）ms。EABR阈值与行为表现和NRT阈值密切相关，而EABR输入-输出功能与行为动态范围（DR）相关。
EABR是客观评估听觉通路功能的有效方法，可用于估计残余螺旋神经节细胞数量。这与国外研究一致，得出DR反映螺旋神经节细胞存活的结论。
