[微小RNA在人类心血管疾病和法医学中的作用及意义]

[The role and significance of microRNA in human cardiovascular disease and forensic science].

作者信息

Li Li-Liang, Zhao Zi-Qin

机构信息

Department of Forensic Medicine, Shanghai Medical College of Fudan University, Shanghai 200032, China.

出版信息

Fa Yi Xue Za Zhi. 2013 Feb;29(1):39-42.

PMID:23646503

Abstract

microRNA (miRNA or miR) is a small single stranded non-coding RNA (21-25nt) that regulates gene expression in almost creatures. Currently, plenty of researches on how miRNA affects human cardiovascular disease have been reported. This review highlights recent findings about the role of miRNA in heart tissue and circulation correlated with human cardiovascular disease and explores the application of miRNA in sudden cardiac death in forensic science.

摘要

微小RNA（miRNA或miR）是一种小的单链非编码RNA（21 - 25个核苷酸），它在几乎所有生物中调节基因表达。目前，已经报道了大量关于miRNA如何影响人类心血管疾病的研究。本综述重点介绍了miRNA在与人类心血管疾病相关的心脏组织和循环中的作用的最新发现，并探讨了miRNA在法医学心脏性猝死中的应用。