对因长期给予异丙肾上腺素而肿大的大鼠腮腺亚细胞膜进行的生化与物理分析。

Biochemical and physical analysis of subcellular membranes in rat parotid gland enlarged by chronic isoproterenol administration.

Mizuno M, Yashiro K, Kameyama Y, Hayashi S, Sakashita Y, Yokota Y

Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu, Japan.

Comp Biochem Physiol B. 1990;96(1):171-6. doi: 10.1016/0305-0491(90)90358-z.

Abstract

Chronic administration of isoproterenol caused similar alterations of membrane lipid profile in at least two rat parotid subcellular fractions, secretory granular and microsomal. 2. Typical changes in phospholipid classes and fatty-acyl chain groups were an increase of phosphatidylcholine and a decrease of sphingomyelin, and an increase of octadecadienoyl chain and a decrease of eicosatetraenoyl chain, respectively. 3. Electron spin resonance study showed that the isoproterenol-treatment also affected a membrane physical property, which may be through these compositional changes in membrane constituents.

摘要

长期给予异丙肾上腺素至少在大鼠腮腺的两个亚细胞组分，即分泌颗粒和微粒体中引起了类似的膜脂质分布变化。2. 磷脂类和脂肪酰链基团的典型变化分别是磷脂酰胆碱增加、鞘磷脂减少，以及十八碳二烯酰链增加、二十碳四烯酰链减少。3. 电子自旋共振研究表明，异丙肾上腺素处理也影响了膜的物理性质，这可能是通过膜成分的这些组成变化实现的。