长期给予异丙肾上腺素诱导的肥大大鼠唾液腺中膜磷脂的改变。

Alteration of membrane phospholipids in hypertrophied rat salivary glands induced by chronic administration of isoproterenol.

作者信息

Yashiro K, Kameyama Y, Mizuno M, Yokota Y

机构信息

Department of Oral Biochemistry, Asahi University School of Dentistry, Gifu, Japan.

出版信息

Arch Oral Biol. 1987;32(11):799-805. doi: 10.1016/0003-9969(87)90006-9.

DOI:10.1016/0003-9969(87)90006-9

PMID:3482349

Abstract

Hypertrophy of parotid and submandibular glands, and elevated phospholipid content per gland in both were induced. However, phospholipid content per tissue weight increased only in the parotid gland. Sublingual gland phospholipids were unaffected with regard to the gland weight and phospholipid content; phospholipid class compositions were altered in each of the three glands, typically an increase of phosphatidylcholine and decreases of sphingomyelin and phosphatidic acid. Concerning fatty-acyl groups in phospholipid, prominent increase of octadecadienoic acid was observed in total and individual phospholipids of both parotid and submandibular glands. However, eicosatetraenoic acid decreased in the total phospholipids of these two glands. In the sublingual gland, phospholipids, fatty-acyl compositions were not changed by isoproterenol. The results suggest that isoproterenol-induced changes of membrane phospholipids are regulated by at least two different effects, one for fatty-acyl groups and another for base moieties of phospholipids.

摘要

腮腺和颌下腺均出现肥大，且两者每腺体的磷脂含量均升高。然而，每组织重量的磷脂含量仅在腮腺中增加。舌下腺的重量和磷脂含量均未受影响；三种腺体中每种腺体的磷脂类组成均发生改变，典型的变化是磷脂酰胆碱增加，鞘磷脂和磷脂酸减少。关于磷脂中的脂肪酰基，在腮腺和颌下腺的总磷脂和单个磷脂中均观察到十八碳二烯酸显著增加。然而，这两个腺体的总磷脂中二十碳四烯酸减少。在舌下腺中，异丙肾上腺素未改变磷脂的脂肪酰组成。结果表明，异丙肾上腺素诱导的膜磷脂变化至少受两种不同效应调节，一种作用于脂肪酰基，另一种作用于磷脂的碱基部分。