脑电图异常作为耐药性癫痫认知共病的生物标志物。
EEG abnormalities as a biomarker for cognitive comorbidities in pharmacoresistant epilepsy.
机构信息
Department of Neurology, Neuroscience Center at Dartmouth, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03756, USA.
出版信息
Epilepsia. 2013 May;54 Suppl 2(0 2):60-2. doi: 10.1111/epi.12186.
Abstract
Cognitive impairment is a common and often devastating comorbidity of pharmacoresistent epilepsy. The cognitive comorbidity can be both chronic, primarily due to the underlying etiology of the epilepsy, and dynamic or evolving because of recurrent seizures or interictal spikes. There is now considerable evidence that interictal spikes can contribute to cognitive impairment. Interictal spikes in both rodents and humans result in transient impairment of memory retrieval, whereas in immature animals, interictal spikes can result in long-term adverse effects on brain development. Interictal spikes therefore contribute to the cognitive impairment in the pharmacoresistant epilepsies. Effective treatment of pharmacoresistant epilepsy needs to target not only the overt seizures but interictal electroencephalography (EEG) abnormalities as well.
摘要
认知障碍是抗药性癫痫的常见且常具破坏性的共病。认知共病可能是慢性的，主要是由于癫痫的潜在病因，也可能是动态的或发展的，因为反复发作或发作间期棘波。现在有相当多的证据表明发作间期棘波可导致认知障碍。无论是在啮齿动物还是人类中，发作间期棘波都会导致记忆检索的短暂障碍，而在不成熟的动物中，发作间期棘波会对大脑发育产生长期的不良影响。因此，发作间期棘波会导致抗药性癫痫的认知障碍。治疗抗药性癫痫不仅需要针对明显的癫痫发作，还需要针对发作间期脑电图（EEG）异常进行治疗。
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