Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.
J Pediatr. 2013 Sep;163(3):811-5. doi: 10.1016/j.jpeds.2013.03.068. Epub 2013 May 3.
To determine the association between Kawasaki disease (KD) and atopic diathesis (atopic dermatitis [AD], allergic rhinitis, and asthma) in children younger than 5 years of age.
In this nationwide study, we aimed to analyze the association and temporal relationship between KD and atopic diathesis. Data were obtained from the National Health Insurance Research Database of Taiwan from 1997 to 2010. In total, 200 patients with KD younger than 5 years of age and 800 age- and sex-matched control subjects were enrolled.
In the whole study population, an increased risk of any concomitant atopic diseases was observed in patients with KD (OR 1.61, 95% CI 1.15-2.26). The risk of AD was increased in male patients between 1 and 5 years of age (OR 3.02, 95% CI 1.22-7.50). More than 60% of the patients developed atopic diseases after the diagnosis of KD.
There appears to be an association between KD and risk of AD. Most of the atopic diseases occurred after the episode of KD.
确定川崎病（KD）与小于 5 岁儿童特应性体质（特应性皮炎[AD]、过敏性鼻炎和哮喘）之间的关系。
在这项全国性研究中，我们旨在分析 KD 和特应性体质之间的关联和时间关系。数据来自台湾 1997 年至 2010 年的全民健康保险研究数据库。总共纳入了 200 例年龄小于 5 岁的 KD 患者和 800 例年龄和性别匹配的对照患者。
在整个研究人群中，KD 患者并发任何特应性疾病的风险增加（OR 1.61，95%CI 1.15-2.26）。1 至 5 岁男性患者患 AD 的风险增加（OR 3.02，95%CI 1.22-7.50）。超过 60%的患者在 KD 诊断后出现特应性疾病。
KD 与 AD 风险之间似乎存在关联。大多数特应性疾病发生在 KD 发作后。
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