Chang Ling-Sai, Huang Ying-Hsien, Chang Hsin-Yu, Lee Zon-Min, Feng Wei-Ling, Kuo Ho-Chang
Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Children (Basel). 2023 Jul 12;10(7):1209. doi: 10.3390/children10071209.
: Patients with Kawasaki disease (KD) are at a significantly increased risk of allergic diseases. Immunoglobulin E (IgE) is an immunoglobulin that mediates allergic sensitization to various allergens and is related to various allergic diseases. However, few studies have analyzed specific IgE on allergy biomarkers after KD is diagnosed. : This study aimed to investigate the pattern of specific IgE levels against food and inhalant allergens. : This retrospective study was conducted in Taiwan to identify patients admitted with KD. A subset of 453 admitted KD children younger than or equal to five years of age with intravenous immunoglobulin (IVIG) was followed up at our clinic with available specific IgE data. : The most common allergens were Dermatophagoides farina or pteronyssinus, house-dust, and cockroach mix. Positive specific IgE for Dermatophagoides farina or pteronyssinus was less common in children diagnosed with KD who were two years old or younger ( = 0.028). KD patients with higher basophils before IVIG ( = 0.010 and 0.018 for two different mites) and higher C-reactive protein (CRP, = 0.030 and 0.028) after IVIG were at higher risk of mite sensitization. Integrated mite sensitization demonstrated higher basophils before IVIG, age at KD diagnosis, and the male sex to be clinically meaningful after logistic regression models. : This study is the first to suggest that specific IgE in KD patients may be correlated with age at KD diagnosis, as well as basophils. Further longitudinal prospective studies are warranted to clarify the unique profile of specific IgE in KD patients.
川崎病（KD）患者患过敏性疾病的风险显著增加。免疫球蛋白E（IgE）是一种介导对各种过敏原过敏致敏的免疫球蛋白，与多种过敏性疾病相关。然而，很少有研究分析KD确诊后过敏生物标志物上的特异性IgE。：本研究旨在调查针对食物和吸入性过敏原的特异性IgE水平模式。：这项回顾性研究在台湾进行，以确定因KD入院的患者。对453名年龄小于或等于5岁且接受静脉注射免疫球蛋白（IVIG）治疗的KD患儿进行了随访，这些患儿在我们诊所拥有可用的特异性IgE数据。：最常见的过敏原是粉尘螨或屋尘螨、屋尘和蟑螂混合物。在2岁及以下被诊断为KD的儿童中，粉尘螨或屋尘螨的特异性IgE阳性较少见（P = 0.028）。IVIG治疗前嗜碱性粒细胞较高（两种不同螨虫分别为P = 0.010和0.018）且IVIG治疗后C反应蛋白（CRP，P = 0.030和0.028）较高的KD患者对螨虫致敏的风险较高。在逻辑回归模型后，综合螨虫致敏显示IVIG治疗前嗜碱性粒细胞较高、KD诊断时的年龄和男性性别具有临床意义。：本研究首次表明，KD患者的特异性IgE可能与KD诊断时的年龄以及嗜碱性粒细胞相关。需要进一步的纵向前瞻性研究来阐明KD患者特异性IgE的独特特征。
