Animal Nutrition Group, Department of Animal Sciences, Wageningen University, Wageningen, The Netherlands.
Comp Biochem Physiol B Biochem Mol Biol. 2013 Jul;165(3):196-200. doi: 10.1016/j.cbpb.2013.04.006. Epub 2013 May 3.
Vitamin D deficiency can lead to several health problems collectively called metabolic bone disease (MBD). One commonly kept reptile species prone to develop MBD if managed incorrectly is the bearded dragon (Pogona vitticeps). This study aimed to determine the extent to which adult female bearded dragons fed a diet low in vitamin D can use stored vitamin D and its metabolites to maintain plasma 25(OH)D(3) and 1,25(OH)(2)D(3) concentrations after discontinuing UVb exposure. Blood samples of healthy adult female bearded dragons, exposed to UVb radiation for over 6 months were collected (day 0) after which UVb exposure was discontinued for 83 days and blood was collected. Blood plasma was analysed for concentrations of total Ca, total P, ionized Ca, uric acid, 25(OH)D(3) and 1,25(OH)(2)D(3). There was no significant change in plasma 25(OH)D(3) and 1,25(OH)(2)D(3) concentrations during the study. While total Ca and P in whole blood was found to significantly decrease over time (P < 0.0088 and 0.0016, respectively), values were within the reference range. Plasma ionized Ca tended (P = 0.0525) to decrease during the study. Adult female bearded dragons, previously exposed to UVb, are able to maintain blood vitamin D metabolite concentrations when UVb exposure is discontinued for a period of up to 83 days.
维生素 D 缺乏会导致多种健康问题，统称为代谢性骨病 (MBD)。如果管理不当，一种常见的被饲养的爬行动物品种——鬃狮蜥（Pogona vitticeps）容易患上 MBD。本研究旨在确定低维生素 D 饮食喂养的成年雌性鬃狮蜥在停止接受 UVb 辐射后，能够在多大程度上利用储存的维生素 D 及其代谢物来维持血浆 25(OH)D(3)和 1,25(OH)(2)D(3)浓度。采集了暴露在 UVb 辐射下超过 6 个月的健康成年雌性鬃狮蜥的血液样本（第 0 天），之后停止 UVb 辐射 83 天并采集血液。分析了血浆中总钙、总磷、离子钙、尿酸、25(OH)D(3)和 1,25(OH)(2)D(3)的浓度。在研究期间，血浆 25(OH)D(3)和 1,25(OH)(2)D(3)浓度没有明显变化。虽然全血中的总钙和磷随着时间的推移显著下降（分别为 P < 0.0088 和 0.0016），但数值仍在参考范围内。血浆离子钙在研究期间呈下降趋势（P = 0.0525）。先前暴露在 UVb 下的成年雌性鬃狮蜥，在停止 UVb 辐射长达 83 天的时间内，能够维持血液维生素 D 代谢物浓度。
