Effect of rhBMP-2 upon maxillary sinus augmentation: a comprehensive review.

PURPOSE

The purpose of this review was to summarize the recent in vitro and in vivo research findings in areas where rhBMP-2 was used as a grafting material for sinus augmentation.

MATERIALS AND METHODS

An electronic literature search for relevant articles published in English was conducted in the PubMed database from February 1996 to August 2012. Randomized clinical trials or prospective human clinical and animal trials were included with the primary objective to compare and evaluate the effectiveness of rhBMP-2 for sinus augmentation.

RESULTS

A total of 3 human studies and 4 animal trials qualified the selection criteria that were included in this review. In humans, the selected studies indicated that rhBMP-2 induces new bone formation with comparable bone quality or amount of newly formed bone to that induced by autogenous bone graft. Furthermore, no differences have been reported between new bone induced by rhBMP-2 and native bone. Animal model studies also demonstrated regular bone formation induced by rhBMP-2, followed by normal maturation of new bone.

CONCLUSION

All these studies demonstrate the osteoinductive and osteogenic capacity of rhBMP-2 and support it as an alternative for autogenous bone in sinus floor augmentation.