Atef M, Youssef S A, Ramadan A, Issa M
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Dtsch Tierarztl Wochenschr. 1990 May;97(5):203-6.
Five clinically health goats were injected with sulfadimethoxine and sulfadimethyloxazole in a single dose of 100 mg/kg b. wt. by intravenous route. Highest concentration levels of sulfadimethoxine and sulfadimethyloxazole in rumen were detected 1 hour following intravenous injection, then the concentration for both compounds declined at 12 and 8 hours post administration, respectively. In addition, both types of sulfonamide completely disappeared in ruminal fluid samples taken after 24 and 12 hours, respectively. The rate of acetylation for sulfadimethoxine and sulfadimethyloxazole were nearly similar and occurred to a high extent in ruminal fluid (22.95 and 23.72%, respectively). On the other hand, both tested drugs increased significantly the ruminal gas production from the first to eight hours after i.v. injection in goats. Changes in the serum enzyme activities (SGOT, SGPT and alkaline phosphatase) observed with sulfadimethoxine and sulfadimethyloxazole, and represented by a significant decrease in the activity of SGOT and SGPT level, alkaline phosphatase 4 hours sulfadimethoxine and in GOT/GPT ratio 24 and 48 hours after i.v. injection, respectively. The creatinine clearance was significantly decreased after 4 hours following the i.v. administration of sulfadimethoxine and sulfadimethyloxazole in goats.
五只临床健康的山羊通过静脉途径注射了单剂量为100毫克/千克体重的磺胺二甲氧嘧啶和磺胺二甲异恶唑。静脉注射后1小时检测到瘤胃中磺胺二甲氧嘧啶和磺胺二甲异恶唑的最高浓度水平，然后两种化合物的浓度分别在给药后12小时和8小时下降。此外，两种磺胺类药物分别在24小时和12小时后采集的瘤胃液样本中完全消失。磺胺二甲氧嘧啶和磺胺二甲异恶唑的乙酰化率几乎相似，且在瘤胃液中高度发生（分别为22.95%和23.72%）。另一方面，两种受试药物在山羊静脉注射后的第一至八小时显著增加了瘤胃气体产生量。观察到磺胺二甲氧嘧啶和磺胺二甲异恶唑引起血清酶活性（谷草转氨酶、谷丙转氨酶和碱性磷酸酶）的变化，表现为谷草转氨酶和谷丙转氨酶水平活性显著降低，静脉注射后4小时碱性磷酸酶降低，24小时和48小时谷草转氨酶/谷丙转氨酶比值降低。山羊静脉注射磺胺二甲氧嘧啶和磺胺二甲异恶唑4小时后肌酐清除率显著降低。
