Sun Guogui, Wang Yadi, Hu Wanning, Li Chengling
Department of Chemoradiotherapy, Tangshan People's Hospital, Tangshan, 06300, China.
Tumour Biol. 2013 Jun;34(3):1409-19. doi: 10.1007/s13277-012-0622-x. Epub 2013 May 7.
Manganese superoxide dismutase (MnSOD) catalyzes superoxide radical (O2 (-)) into hydrogen peroxide (H2O2), which is further catalyzed by the combined action of glutathione peroxidase (GPx) and catalase (CAT) into water and oxygen. MnSOD plays a role in cell protection from superoxide damage. This study aimed to investigate the effects of MnSOD on regulation of esophageal squamous cell carcinoma cell growth, apoptosis, and cell cycle distribution in vitro and tumor formation and growth in nude mouse xenografts. The data showed that differential levels of MnSOD expression had different effects on tumor cell proliferation, apoptosis, plating efficiency (PE), and cell cycle distribution in vitro and tumor formation and growth in nude mice. In particular, high levels of MnSOD expression promoted TE-1 cell growth and PE rate in vitro and in nude mice, whereas moderate MnSOD expression suppressed tumor cell growth and PE rate but induced more cell apoptosis. Thus, these data demonstrated the dual effects of MnSOD protein in esophageal squamous cell carcinoma and further study will confirm these current data.
锰超氧化物歧化酶（MnSOD）将超氧阴离子自由基（O2 (-)）催化生成过氧化氢（H2O2），过氧化氢在谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）的共同作用下进一步被催化生成水和氧气。MnSOD在保护细胞免受超氧化物损伤方面发挥作用。本研究旨在探讨MnSOD对体外食管鳞状细胞癌细胞生长、凋亡及细胞周期分布的调控作用，以及对裸鼠异种移植瘤形成和生长的影响。数据表明，不同水平的MnSOD表达对肿瘤细胞增殖、凋亡、接种效率（PE）、体外细胞周期分布以及裸鼠体内肿瘤形成和生长具有不同影响。特别是，高水平的MnSOD表达在体外和裸鼠体内均促进TE-1细胞生长和PE率，而中等水平的MnSOD表达则抑制肿瘤细胞生长和PE率，但诱导更多细胞凋亡。因此，这些数据证明了MnSOD蛋白在食管鳞状细胞癌中的双重作用，进一步研究将证实这些现有数据。
