海星皂苷 goniopectenoside B 的全合成。
Total synthesis of starfish saponin goniopectenoside B.
机构信息
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China.
出版信息
Chemistry. 2013 Jun 10;19(24):7708-12. doi: 10.1002/chem.201301186. Epub 2013 May 6.
Star quality: Goniopectenoside B, a minor asterosaponin from starfish Goniopecten demonstrans with antifouling activity, has been synthesized in a convergent 21 steps and in 4.3 % overall yield starting from adrenosterone. This represents the first synthesis of a complex asterosaponin, which are ubiquitous and characteristic in starfish as defense chemicals (see figure).
星质量
来自星盘 Goniopecten demonstrans 的次要甾醇皂苷 Goniopectenoside B 具有抗污活性，已从肾上腺酮出发，通过 21 步的收敛性合成，以 4.3%的总收率合成。这代表了复杂甾醇皂苷的首次合成，这些皂苷在海星中普遍存在且是其作为防御化学物质的特征（见图）。
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