知母皂苷元3 - O - β - D - 吡喃葡萄糖基 -（1→3）-[α - L - 吡喃鼠李糖基 -（1→2）]-β - D - 吡喃葡萄糖苷的合成

The synthesis of pennogenin 3-O-β-D-glucopyranosyl-(1 → 3)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside.

作者信息

Luo Xin-Feng, Lei Fan, He Yi, Pei Shu-Chen, Hai Li, Qian Shan, Wu Yong

机构信息

Key Laboratory of Drug Targeting and Drug Delivery Systems of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

出版信息

J Asian Nat Prod Res. 2012;14(4):314-21. doi: 10.1080/10286020.2011.653348.

DOI:10.1080/10286020.2011.653348

PMID:22375868

Abstract

Pennogenin 3-O-β-D-glucopyranosyl-(1 → 3)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside, a monodesmosidic saponin isolated from Paris polyphylla Smith var. yunnanensis with promised antitumor activities, was firstly synthesized from glucoside thiol via nine steps and with 27% overall yield.

摘要

重楼皂苷Ⅶ，一种从云南重楼中分离得到的具有抗肿瘤活性的单糖链皂苷，首次通过硫醇糖苷经九步反应合成，总收率为27%。