有机催化对映选择性直接 vinylogous Michael 加成γ-取代丁烯内酯到 3-芳基丙烯酸盐和 1,2-二芳基乙烯。
Organocatalytic enantioselective direct vinylogous Michael addition of γ-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes.
机构信息
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.
出版信息
Chemistry. 2013 Jun 10;19(24):7713-7. doi: 10.1002/chem.201301332. Epub 2013 May 6.
PMID:23649965
Abstract
Adding value: The direct vinylogous Michael addition of γ-substituted butenolides with a series of 3-aroyl acrylates and 1,2-diaroylethylenes has been demonstrated. This organocatalytic method delivers highly enantio- and diastereomerically pure γ,γ-disubstituted butenolides with adjacent quaternary and tertiary stereocenters (see scheme).
摘要
增值
已证明γ-取代丁烯内酯与一系列 3-芳基丙烯酸盐和 1,2-二芳基乙烯的直接 vinylogous Michael 添加反应。这种有机催化方法提供了高度对映体和非对映体纯的γ,γ-二取代丁烯内酯，具有相邻的季和叔立体中心（见方案）。
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