Miami Valley Hospital, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45409, USA.
Pharmacotherapy. 2013 Jul;33(7):e166-9. doi: 10.1002/phar.1286. Epub 2013 May 3.
We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug-induced eosinophilic pneumonia.
我们报告了一例因使用头孢洛林治疗耐甲氧西林金黄色葡萄球菌菌血症相关的术后脊柱感染而引起的嗜酸性肺炎。我们的患者在使用头孢洛林治疗的第五周出现呼吸急促和低氧血症。胸部影像学显示弥漫性双侧浸润影。实验室异常包括外周血嗜酸性粒细胞增多和嗜酸性粒细胞为主的支气管肺泡灌洗液。头孢洛林停药联合激素治疗的结果是完全缓解了体征、症状和影像学异常。我们推测了这种不良事件的可能机制和药物诱导性嗜酸性肺炎的诊断标准。
