Vanin A F, Borodulin R R, Kubrina L N, Mikoian V D, Burbaev D Sh
Biofizika. 2013 Jan-Feb;58(1):126-36.
Current notions and new experimental data of the authors on physico-chemical features of dinitrosyl iron complexes with natural thiol-containing ligands (glutathione or cysteine), underlying the ability of the complexes to act as NO molecule and nitrosonium ion donors, are considered. This ability determines various biological activities of dinitrosyl iron complexes--inducing long-lasting vasodilation and thereby long-lasting hypotension in human and animals, inhibiting pellet aggregation, increasing red blood cell elasticity, thereby stimulating microcirculation, and reducing necrotic zone in animals with myocardial infarction. Moreover, dinitrosyl iron complexes are capable of accelerating skin wound healing, improving the function of penile cavernous tissue, blocking apoptosis development in cell cultures. When decomposed dinitrosyl iron complexes can exert cytotoxic effect that can be used for curing infectious and carcinogenic pathologies.
本文探讨了作者关于二亚硝基铁配合物与天然含硫醇配体（谷胱甘肽或半胱氨酸）的物理化学特性的当前观点和新实验数据，这些特性是配合物作为一氧化氮分子和亚硝鎓离子供体的能力的基础。这种能力决定了二亚硝基铁配合物的各种生物活性——在人和动物中诱导持久的血管舒张从而导致持久的低血压，抑制血小板聚集，增加红细胞弹性从而促进微循环，并减少心肌梗死动物的坏死区域。此外，二亚硝基铁配合物能够加速皮肤伤口愈合，改善阴茎海绵体组织的功能，阻止细胞培养中的细胞凋亡发展。当二亚硝基铁配合物分解时，它们可以发挥细胞毒性作用，可用于治疗感染性和致癌性疾病。
