Feitelson M A, Clayton M M
Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Gastroenterology. 1990 Aug;99(2):500-7. doi: 10.1016/0016-5085(90)91033-3.
Antibodies to the X antigen of hepatitis B virus and woodchuck hepatitis virus were assayed in serial sera from infected individuals and compared with other markers of infection. Antibody to the X antigen was found in 11 of 17 (65%) patients and 17 of 40 (42%) woodchucks that were surface-antigen positive. In comparison, this antibody was found in 5 of 14 (36%) patients and in none of 4 woodchucks that were surface-antigen negative. In 5 of 6 patients showing seroconversion from hepatitis B e antigen to antibody, antibody to X appeared at or near the time of seroconversion. In patients persistently positive for e antigen, X antibody often appeared when viral DNA became undetectable in the serum. In 14 of 17 (82%) woodchucks positive for antibody to X antigen, it also appeared near or after the time that viral DNA in serum disappeared. X antibodies were detected with great frequency only in populations with high frequencies of other hepatitis B virus markers. The results are consistent with the conclusion that antibody to X antigen is a marker of hepadnavirus infections that seems to be associated with a decrease in viral replication. Antibodies to the X antigen, then, may be a host response to the replication complex of the virus.
对感染个体的系列血清检测了针对乙型肝炎病毒和土拨鼠肝炎病毒X抗原的抗体，并与其他感染标志物进行了比较。在17例表面抗原阳性患者中的11例（65%）以及40只表面抗原阳性土拨鼠中的17只（42%）检测到了X抗原抗体。相比之下，在14例表面抗原阴性患者中的5例（36%）检测到了该抗体，而在4只表面抗原阴性土拨鼠中均未检测到。在6例从乙型肝炎e抗原血清学转换为抗体的患者中，有5例在血清学转换时或接近血清学转换时出现了X抗体。在e抗原持续阳性的患者中，当血清中病毒DNA检测不到时，X抗体常出现。在17只X抗原抗体阳性的土拨鼠中，有14只（82%）在血清中病毒DNA消失时或之后也出现了该抗体。仅在其他乙型肝炎病毒标志物频率较高的人群中频繁检测到X抗体。这些结果与以下结论一致：X抗原抗体是嗜肝DNA病毒感染的一个标志物，似乎与病毒复制的减少有关。因此，X抗原抗体可能是宿主对病毒复制复合体的一种反应。
