Department of Neurology, Singapore General Hospital, Singapore; National Neuroscience Institute, Singapore, Singapore.
Neurobiol Aging. 2013 Oct;34(10):2441.e7-8. doi: 10.1016/j.neurobiolaging.2013.04.012. Epub 2013 May 4.
The rare variant A673T in the amyloid-β precursor protein (APP) gene has been shown to reduce the risk of cognitive impairment. We genotyped the variant in 8721 Asian individuals comprising 552 with Alzheimer's disease and vascular dementia, 790 with Parkinson's disease, and 7379 controls. The A673T variant was absent in all of the subjects. Our finding suggests that the A673T protective variant is not relevant in our Asian population. Studies in other ethnic populations would clarify whether this variant is specific to specific races/ethnicities.
在淀粉样前体蛋白（APP）基因中罕见的 A673T 变异已被证明可降低认知障碍的风险。我们对包括 552 名阿尔茨海默病和血管性痴呆患者、790 名帕金森病患者和 7379 名对照者在内的 8721 名亚洲个体进行了该变异的基因分型。在所有受试者中均未发现 A673T 变异。我们的发现表明，A673T 保护性变异在我们的亚洲人群中并不相关。在其他种族人群中的研究将阐明该变异是否仅存在于特定种族/民族中。
