Donahue P E, Carvalho P J, Davis P E, Shen Y J, Miidla I, Bombeck C T, Nyhus L M
Department of Surgery, University of Illinois, Chicago.
Gastrointest Endosc. 1990 May-Jun;36(3):253-6. doi: 10.1016/s0016-5107(90)71017-6.
Surgical anti-reflux therapy appears to involve the muscles of the proximal gastric cardia and those of the lower esophageal sphincter. In an experimental canine reflux model, we injected sclerosant solution into the submucosa of the proximal gastric cardia, hypothesizing that the subsequent fibrotic reaction might exert an anti-reflux effect. Reflux was induced by atropine infusion, and the amount of reflux was quantitated by pH monitoring. Endoscopic sclerosis was effective in preventing reflux induced by high-dose atropine. Because the length and pressure of the lower esophageal sphincter were unaffected by endoscopic treatment, reflux prevention was possibly related to enhancement of the gastric component of the reflux barrier.
手术抗反流治疗似乎涉及胃贲门近端的肌肉和食管下括约肌的肌肉。在一个实验性犬反流模型中，我们将硬化剂溶液注入胃贲门近端的黏膜下层，推测随后的纤维化反应可能发挥抗反流作用。通过输注阿托品诱导反流，并通过pH监测对反流的量进行定量。内镜下硬化术可有效预防高剂量阿托品诱导的反流。由于内镜治疗未影响食管下括约肌的长度和压力，反流的预防可能与反流屏障的胃成分增强有关。
