烷基铵衍生物6-甲基尿嘧啶对大鼠平滑肌和横纹肌乙酰胆碱酯酶的特异性抑制作用。 - Suppr

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Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.

作者信息

Nikitashina A D, Petrov K A, Zobov V V, Reznik V S, Nikol'skii E E

机构信息

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.

出版信息

Dokl Biol Sci. 2013 Mar;449:82-4. doi: 10.1134/S0012496613020099. Epub 2013 May 8.

DOI:10.1134/S0012496613020099

PMID:23652433

Abstract

摘要

相似文献

Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.

Dokl Biol Sci. 2013 Mar;449:82-4. doi: 10.1134/S0012496613020099. Epub 2013 May 8.

Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).

Br J Pharmacol. 2011 Jun;163(4):732-44. doi: 10.1111/j.1476-5381.2011.01211.x.

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Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

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Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells.

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Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment.

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C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies.

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Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction.

Bull Exp Biol Med. 2001 May;131(5):446-50. doi: 10.1023/a:1017967730137.

Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation.

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本文引用的文献

Neostigmine for the treatment of acute colonic pseudo-obstruction (ACPO) in pediatric hematologic malignancies.

Korean J Hematol. 2010 Mar;45(1):62-5. doi: 10.5045/kjh.2010.45.1.62. Epub 2010 Mar 31.

Physiol Res. 2009;58(1):149-153. doi: 10.33549/physiolres.931698.

Clinical limitations of acetylcholinesterase antagonists.

J Crit Care. 2009 Mar;24(1):21-8. doi: 10.1016/j.jcrc.2008.08.003. Epub 2009 Jan 17.

Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

J Cardiovasc Pharmacol. 2009 Feb;53(2):162-6. doi: 10.1097/FJC.0b013e31819867d1.

Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation.

J Neuroimmunol. 2008 Sep 15;201-202:121-7. doi: 10.1016/j.jneuroim.2008.05.022. Epub 2008 Aug 5.

How myasthenia gravis alters the safety factor for neuromuscular transmission.

J Neuroimmunol. 2008 Sep 15;201-202:13-20. doi: 10.1016/j.jneuroim.2008.04.038. Epub 2008 Jul 15.

The origin of the molecular diversity and functional anchoring of cholinesterases.

Neurosignals. 2002 May-Jun;11(3):130-43. doi: 10.1159/000065054.

Long term outcome in Lambert-Eaton myasthenic syndrome without lung cancer.

J Neurol Neurosurg Psychiatry. 2001 Feb;70(2):212-7. doi: 10.1136/jnnp.70.2.212.

Promoter elements and transcriptional regulation of the acetylcholinesterase gene.

DNA Cell Biol. 1993 Jan-Feb;12(1):63-72. doi: 10.1089/dna.1993.12.63.

Monitoring of neuromuscular function.

Anesthesiology. 1976 Aug;45(2):216-49. doi: 10.1097/00000542-197608000-00009.

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Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.

作者信息

Nikitashina A D, Petrov K A, Zobov V V, Reznik V S, Nikol'skii E E

机构信息

Kazan Institute of Biochemistry and Biophysics, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.

出版信息

Dokl Biol Sci. 2013 Mar;449:82-4. doi: 10.1134/S0012496613020099. Epub 2013 May 8.

DOI:10.1134/S0012496613020099

PMID:23652433

Abstract

摘要

相似文献

Specific inhibitory effects of the alkylammonium derivative 6-methyluracil on acetylcholinesterase of smooth and striated muscles in rats.

Dokl Biol Sci. 2013 Mar;449:82-4. doi: 10.1134/S0012496613020099. Epub 2013 May 8.

Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS).

Br J Pharmacol. 2011 Jun;163(4):732-44. doi: 10.1111/j.1476-5381.2011.01211.x.

Physiol Res. 2009;58(1):149-153. doi: 10.33549/physiolres.931698.

Different sensitivity of miniature endplate currents of the rat extensor digitorum longus, soleus and diaphragm muscles to a novel acetylcholinesterase inhibitor C-547.

Physiol Res. 2006;55(5):585-589. doi: 10.33549/physiolres.930980. Epub 2006 Jun 22.

Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

J Cardiovasc Pharmacol. 2009 Feb;53(2):162-6. doi: 10.1097/FJC.0b013e31819867d1.

Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells.

Eur J Pharmacol. 2012 Aug 5;688(1-3):22-6. doi: 10.1016/j.ejphar.2012.05.010. Epub 2012 May 23.

Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment.

Sci Rep. 2018 Jan 10;8(1):304. doi: 10.1038/s41598-017-18307-9.

C-547, a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase: Pharmacokinetic and pharmacodynamic studies.

Neuropharmacology. 2018 Mar 15;131:304-315. doi: 10.1016/j.neuropharm.2017.12.034. Epub 2017 Dec 24.

Effect of tetraalkylammonium derivative of 6-methyluracil on amplitude and temporal parameters of miniature endplate potentials in frog neuromuscular junction.

Bull Exp Biol Med. 2001 May;131(5):446-50. doi: 10.1023/a:1017967730137.

Dokl Biol Sci. 2007 Jul-Aug;415:261-4. doi: 10.1134/s0012496607040035.

本文引用的文献

Neostigmine for the treatment of acute colonic pseudo-obstruction (ACPO) in pediatric hematologic malignancies.

Korean J Hematol. 2010 Mar;45(1):62-5. doi: 10.5045/kjh.2010.45.1.62. Epub 2010 Mar 31.

Physiol Res. 2009;58(1):149-153. doi: 10.33549/physiolres.931698.

Clinical limitations of acetylcholinesterase antagonists.

J Crit Care. 2009 Mar;24(1):21-8. doi: 10.1016/j.jcrc.2008.08.003. Epub 2009 Jan 17.

Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547.

J Cardiovasc Pharmacol. 2009 Feb;53(2):162-6. doi: 10.1097/FJC.0b013e31819867d1.

Acetylcholinesterase inhibitors and cholinergic modulation in Myasthenia Gravis and neuroinflammation.

J Neuroimmunol. 2008 Sep 15;201-202:121-7. doi: 10.1016/j.jneuroim.2008.05.022. Epub 2008 Aug 5.

How myasthenia gravis alters the safety factor for neuromuscular transmission.

J Neuroimmunol. 2008 Sep 15;201-202:13-20. doi: 10.1016/j.jneuroim.2008.04.038. Epub 2008 Jul 15.

The origin of the molecular diversity and functional anchoring of cholinesterases.

Neurosignals. 2002 May-Jun;11(3):130-43. doi: 10.1159/000065054.

Long term outcome in Lambert-Eaton myasthenic syndrome without lung cancer.

J Neurol Neurosurg Psychiatry. 2001 Feb;70(2):212-7. doi: 10.1136/jnnp.70.2.212.

Promoter elements and transcriptional regulation of the acetylcholinesterase gene.

DNA Cell Biol. 1993 Jan-Feb;12(1):63-72. doi: 10.1089/dna.1993.12.63.

Monitoring of neuromuscular function.

Anesthesiology. 1976 Aug;45(2):216-49. doi: 10.1097/00000542-197608000-00009.