From the *Department of Pediatrics, Stanford University, Palo Alto, CA; †Department of Clinical Pharmacy, University of California San Francisco, CA; and ‡Department of Pediatrics, University of Utah, Salt Lake City, UT.
Pediatr Infect Dis J. 2013 Oct;32(10):1077-9. doi: 10.1097/INF.0b013e318299f75c.
Vancomycin area under the curve/minimal inhibitory concentration (AUC/MIC) >400 best predicts the outcome when treating invasive methicillin-resistant Staphylococcus aureus infection; however, trough serum concentrations are used clinically to assess the appropriateness of dosing. We used pharmacokinetic modeling and simulation to examine the relationship between vancomycin trough values and AUC/MIC in children receiving vancomycin 15 mg/kg every 6 hours and methicillin-resistant Staphylococcus aureus MIC of 1 μg/mL. A trough of 7-10 μg/mL predicted achievement of AUC/MIC >400 in >90% of children.
当治疗侵袭性耐甲氧西林金黄色葡萄球菌感染时，万古霉素曲线下面积/最小抑菌浓度（AUC/MIC）>400 预测结果最佳；然而，临床中常通过谷浓度来评估剂量的合理性。我们使用药代动力学建模和模拟来研究万古霉素 15mg/kg 每 6 小时给药且耐甲氧西林金黄色葡萄球菌 MIC 为 1μg/mL 的儿童中，万古霉素谷浓度与 AUC/MIC 之间的关系。谷浓度为 7-10μg/mL 时，预测超过 90%的儿童 AUC/MIC>400 达标。
