Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland.
Department of Pediatrics, Children's National Health System, Washington, DC.
J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):338-341. doi: 10.1093/jpids/pix068.
In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.
在一项多中心回顾性研究中，我们试图确定最佳的万古霉素谷浓度，以影响儿童耐甲氧西林金黄色葡萄球菌菌血症的持续时间。我们发现，与万古霉素谷浓度≥10μg/ml 相比，前 72 小时内中位数＜10μg/ml 的万古霉素谷浓度可能与更长的菌血症持续时间相关。
