万古霉素谷浓度与儿童耐甲氧西林金黄色葡萄球菌菌血症持续时间的关系。
Association Between Vancomycin Trough Concentrations and Duration of Methicillin-Resistant Staphylococcus aureus Bacteremia in Children.
机构信息
Department of Pharmacy, The Johns Hopkins Hospital, Baltimore, Maryland.
Department of Pediatrics, Children's National Health System, Washington, DC.
出版信息
J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):338-341. doi: 10.1093/jpids/pix068.
In a multicenter retrospective study, we sought to determine the optimal vancomycin trough concentration that would impact the duration of methicillin-resistant Staphylococcus aureus bacteremia in children. We found that a median vancomycin trough concentration of <10 µg/mL within the first 72 hours may be associated with a longer duration of bacteremia compared to a median trough concentration of ≥10 µg/mL.
在一项多中心回顾性研究中，我们试图确定最佳的万古霉素谷浓度，以影响儿童耐甲氧西林金黄色葡萄球菌菌血症的持续时间。我们发现，与万古霉素谷浓度≥10μg/ml 相比，前 72 小时内中位数＜10μg/ml 的万古霉素谷浓度可能与更长的菌血症持续时间相关。
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