Taoyuan Mental Hospital, Department of Health, No. 71, Longshow Street, Taoyuan, 33058, Taiwan.
Soc Psychiatry Psychiatr Epidemiol. 2013 Dec;48(12):1889-96. doi: 10.1007/s00127-013-0702-2. Epub 2013 May 8.
We used Taiwan's population-based National Health Insurance database to investigate the trends, correlates, and disease patterns of antipsychotic use among children and adolescents.
The National Health Research Institutes provided a database of 1,000,000 random subjects for study. We chose subjects who were aged 18 years or younger during 1997-2005. In this sample, subjects who were given at least one antipsychotic prescription, including first-generation antipsychotics (FGAs) or second-generation antipsychotics (SGAs), were identified. Trends, prevalence, and associated factors of antipsychotic use were determined. The proportion of antipsychotic use for psychiatric and medical disorders was also analyzed.
The 1-year prevalence of SGA use increased from 0.00 % in 1997 to 0.09 % in 2005, whereas the 1-year prevalence of FGA use ranged from 2.24 to 3.43 % during this same period, with no significant change. Age and male gender were associated with higher SGA use. Among SGA users, the greatest proportion suffered from psychiatric disorders, including tics, hyperkinetic syndrome of childhood, schizophrenia, affective disorders, and autism. Among FGA users, a larger proportion was for medical conditions, including diseases of the digestive and respiratory systems.
The prevalence of pediatric SGA use increased greatly from 1997 to 2005. Among pediatric subjects using antipsychotics, SGAs were mostly used for psychiatric disorders, whereas FGAs were mostly prescribed for medical conditions. Future research will focus on indication, dosage, frequency, duration, adverse effects, and off-label use of antipsychotics in the pediatric population.
我们利用台湾全民健康保险数据库，调查儿童和青少年使用抗精神病药物的趋势、相关因素和疾病模式。
国立健康研究院提供了一个由 100 万随机抽样个体组成的数据库，我们选择了 1997 年至 2005 年期间年龄在 18 岁或以下的个体。在此样本中，我们确定了至少使用过一种抗精神病药物（包括第一代抗精神病药物（FGAs）或第二代抗精神病药物（SGAs）的个体。确定了抗精神病药物使用的趋势、流行率和相关因素，并分析了用于精神和医学疾病的抗精神病药物的比例。
1 年 SGA 使用的流行率从 1997 年的 0.00%增加到 2005 年的 0.09%，而同期 FGA 使用的 1 年流行率范围在 2.24%至 3.43%之间，没有显著变化。年龄和男性与 SGA 使用率较高相关。在 SGA 使用者中，最大比例的人患有精神疾病，包括抽动症、儿童多动综合征、精神分裂症、情感障碍和自闭症。在 FGA 使用者中，更大比例的人患有医疗条件，包括消化系统和呼吸系统疾病。
1997 年至 2005 年，儿科 SGA 使用的流行率大大增加。在使用抗精神病药物的儿科患者中，SGAs 主要用于精神疾病，而 FGAs 主要用于医疗条件。未来的研究将集中在儿科人群中抗精神病药物的适应证、剂量、频率、持续时间、不良反应和标签外使用。
